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Depo Provera injection is used to treat women who have irregular or absent periods or who have periods that last longer than four years. Injection is also used for the management of menstrual pain and for the prevention of future abortions. Depo Provera injection contains medroxyprogesterone acetate (MPA) as the active ingredient.

Depo-Provera injection contains the active ingredient medroxyprogesterone acetate.

Injection is injected in the buttock or upper arm (front of thigh), buttock, or upper back.

Depo-Provera injection can be given with or without food.

Depo-Provera injection is given by intramuscular injection, and is given every three months.

What are the side effects of Depo Provera injection?

The most common side effects of Depo-Provera injection are abdominal pain, fluid retention, breast tenderness, weight gain, and vaginal discharge. The most common side effect of Depo-Provera injection is an increased risk of breast cancer.

The serious side effects associated with Depo-Provera injection include an increased risk of developing bone fractures, bone loss, and an increased risk of developing bone and blood clots. Injection may also cause a decrease in the amount of urine produced by the kidneys.

What are the side effects of Depo-Provera injection?

The following side effects have been reported in association with Depo-Provera injection:

  • Pain in the lower back, neck, and upper back
  • Pain in the upper legs and feet
  • Pain in the upper arms, hands, and lower legs
  • Pain in the feet, ankles, or legs
  • Pain in the brain, stomach, or abdomen
  • Pain in the breasts
  • Pain in the hands
  • Pain in the hands and feet
  • Pain in the mouth or vagina
  • Pain in the eyes, mouth, or vagina
  • Pain in the eyes or mouth
  • Pain in the eyes
  • Pain in the stomach
  • Pain in the lower back or lower legs
  • Pain in the lower legs
  • Pain in the legs

If any of the following applies to you:

  • You have a history of kidney or bladder cancer
  • You are pregnant, breastfeeding, or plan to become pregnant, are taking other drugs or medicines, or are taking other medicines that can affect the Depo-Provera injection
  • You have had a stroke or a bleeding disorder
  • You have had an eye disease, eye surgery, or had an eye infection, or you have had a stroke, or you have had a bleeding disorder
  • You have a severe liver or kidney problem
  • You are taking a steroid medicine (injectable), or you have a blood disorder or you are taking other medicines for the blood disorder or you are taking blood thinning medicines.

Background

Depo-Provera (medroxyprogesterone acetate) is a synthetic hormone that is administered via injection. Depo-Provera is primarily used to prevent pregnancy and to control the effects of certain cancers in women who are at risk for cancer progression. Depo-Provera, however, is contraindicated in pregnancy due to its potential to cause fetal harm in the unborn. Because of its potential to cause birth defects, there is a growing concern that this medication may also be used during pregnancy. The risks of pregnancy associated with Depo-Provera in pregnant women are well known.

Objectives

To determine the effect of Depo-Provera on pregnancy outcomes in women with congenital brain tumors. Outcomes for women taking Depo-Provera from an international randomized study were evaluated.

Methods

This was a single center retrospective analysis of records for 936 women enrolled from March 2004 to January 2017. The records included women who had either first- or second-line use of Depo-Provera from a US national registry and were assessed for pregnancy outcomes using the following variables: (1) age, (2) smoking status, and (3) pregnancy outcome (including birth defects or malformation).

Results

Of the 936 women enrolled, 39.5% of them had a first-line use of Depo-Provera from the national registry. Of these 39 women, 51.6% had an initial use of Depo-Provera from the registry. After receiving the second-line form of Depo-Provera, 39.5% of women who had an initial use of Depo-Provera were either pregnant or still trying to get pregnant. However, a further 23.3% of women received a second-line form of Depo-Provera. In these women, 51.6% had an initial use of Depo-Provera and 34.9% of women had a pregnancy or still trying to get pregnant. Of the 39 women that did not have a pregnancy, the remaining 59.5% were still trying to get pregnant.

Conclusions

The effects of Depo-Provera on pregnancy in women with congenital brain tumors may be similar to those in women who were previously using another hormone replacement therapy (HRT). The overall prognosis for women using Depo-Provera is poor, and there are no specific outcomes that can be expected with the use of Depo-Provera in pregnancy. However, there is a growing concern that this medication may also be used during pregnancy. The risk of pregnancy associated with Depo-Provera may be similar to those in women who were previously using another HRT or other hormonal therapies, including hormone replacement therapy (HRT).

Citation: Depo-Provera in pregnancy: implications for obstetric care. PLoS ONE 14(12): e0129123. https://doi.org/10.1371/journal.pone.0129123

Editor:F. R. Thompson, Royal College of Obstetric and Gynaecological Surgeons (ROCOG) and the UK Clinical and Laboratory Service, University of Oxford

Received:April 11, 2018;Accepted:August 7, 2018;Published:September 8, 2018

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Copyright© 2018 Clearsen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original is properly cited.

FundingFunding was provided by the National Institute for Health Research (NIHR), funded by the R01-HD084133 (Lloyd et al.) and the National Institute of Child Health and Human Development (NICHD) funded by the National Institute for Health Research

Competing interests:The authors have declared that no competing interests exist.

Description

WHAT ARE THE SIDE EFFECTS OF MELRODINE (Depo-Provera)?

Depo-Provera, also known as medroxyprogesterone acetate, is a hormone medication used to manage certain types of menstrual disorders, including, irregular cycles, and. MELODINE is a synthetic progestin that mimics the effects of estrogen in a hormone-dependent manner. By doing so, you can manage or prevent unwanted pregnancies and improve your overall health. Here’s how it works:

  • Human Menopausal Gonadotropin Releasing Hormone (hGHR): MELODINE mimics the natural progesterone in the body that causes ovulation.
  • MELODINE Promotes Bone Loss: MELODINE is also known to have anti-estrogen effects. By suppressing the production of estrogen, MELODINE helps prevent and manage some types of menopause symptoms.
  • MELODINE May Decrease Bone Density: MELODINE may also reduce bone density in some women. It’s not just a short-term solution for women who have difficulty absorbing estrogen.
  • MELODINE May Increase Bone Thickness and Mineral Density: MELODINE may also increase the risk of developing brittle bones (osteopenia) and osteoporosis, especially in older women who are at higher risk for this condition.
  • MELODINE May Cause Hypothalamic Amenorrhea: MELODINE may cause a condition called hypothalamic amenorrhea (which involves a decreased release of luteinizing hormone and estrogen). If you have this problem, talk to your doctor to find out whether MELODINE may be right for you.

For more information about MELODINE, see here:.

What is MELODINE?

MELODINE is a progestin hormone. It’s the hormone that makes your body produce progesterone, a natural substance that stops the menstrual cycle from happening. The progestin is used to prevent and treat certain conditions, including,,, and.

When you take MELODINE, your body produces estrogen, which helps produce and regulate the menstrual cycle. Estrogen is a female sex hormone. MELODINE mimics the effects of estrogen in a hormone-dependent manner, which allows for more of your body to produce hormones and regulate your menstrual cycle.

It may help to know that MELODINE is a progestin hormone and that estrogen is a female sex hormone. MELODINE is not an estrogen, and it is not a female sex hormone. It does not stimulate ovulation.

HOW TO TAKE MELODINE?

You can take MELODINE if you have:

  • Menopausal symptoms such as hot flashes, mood swings, and/or breast tenderness;
  • Nausea, vomiting, or diarrhea;
  • A decrease in bone density, which can make it more difficult for bones to grow; or
  • Stress and depression that can lead to mood changes and anxiety.

WHAT ARE THE SIDE EFFECTS OF MELODINE?

MELODINE may cause some side effects. Common side effects may include:

  • Hot flashes;
  • Mood swings, depression, irritability, and/or sleep disorders;
  • Headaches;
  • Weight changes;
  • Nausea and vomiting;
  • Vomiting;
  • Mood swings, depression, and irritability; or
  • Sexual side effects such as decreased sex drive, low libido, and/or difficulty achieving an erection.

FAQs ABOUT PROVERA 10MG TABLET

Q: What is PROVERA 10MG TABLET used for?

A: PROVERA 10MG TABLET is used in to maintain a balance on menstrual cycle and controls abnormal tissue growth in uterus.

Q: How does PROVERA 10MG TABLET regulate menstrual cycle?

A: PROVERA 10MG TABLET works by stopping the production of gonadotropin hormone, which is responsible for maturation of cells in the ovary and the process of releasing mature egg from the ovary (ovulation) to avoid pregnancy. This kind of action provides relief from unpleasant period symptoms.

Q: For how long should you take PROVERA 10MG TABLET?

A: Your doctor might advise you on how long you should continue to take PROVERA 10MG TABLET. You will need to consult your doctor from time to time to review your management and assess your symptoms. Do not stop taking PROVERA 10MG TABLET on your own.

Q: Can PROVERA 10MG TABLET be used during pregnancy?

A: PROVERA 10MG TABLET is not recommended for use in pregnant women as it can affect the developing baby. If you think you are pregnant or planning to have baby or have a history of repeated miscarriage, inform your doctor before taking PROVERA 10MG TABLET. Use other methods of contraceptives while taking this medicine.

Q:IsPROVERA 10MG TABLET safe to use in patients with heart problems?

A: PROVERA 10MG TABLET is not recommended for use if patient had a stroke or heart attack in the past years. It should be taken with caution in patients with heart problems and high blood pressure. Consult your doctor before taking PROVERA 10MG TABLET.

How long does it take PROVERA 10MG TABLET to work?

How PROVERA 10MG TABLET work?

A: PROVERA 10MG TABLET works by releasing miotics (progesterone) on the day of conception by releasing oestrogen on the same day as your first menstrual cycle. It works by keeping o synthetic progestaglandine (dihydrotestosterone (DHT) in the blood) in the body very close to its production in the body. So, when you have your first menstrual cycle, release o natural progestaglandine (DHT) in your body very close to the production in the body. As the production in the body gets higher, the o natural progestaglandine (DHT) levels in your body get increased. PROVERA 10MG TABLET works only in healthy body parts (such as the penis, womb, back pain, muscles etc). In addition, it should not be taken by women who are pregnant or breastfeeding. It is intended for use in the management of erectile dysfunction (ED) in women.

A: A dutasteride pill is a long-term method of treatment. It should be taken every day as per the doctor’s prescription.

A: PROVERA 10MG TABLET is not recommended for use if patient has liver or kidney problems. It should be taken once a day with or without food.

A: It is not known if PROVERA 10MG TABLET is harmful if taken by women who are pregnant or breastfeeding. Avoid using with alcohol and tobacco after taking PROVERA 10MG TABLET as these preparations are generally more harmful to your body. You must talk to your doctor if you are worried about the effects of PROVERA 10MG TABLET.

As the use of this medicine is not recommended in patients with kidney, liver or heart problems, it is not recommended for use. It is better to let your doctor know if you have the disease himself or experience it on physical examination.

For Further Details

How long do I take PROVERA 10MG TABLET?

A:

I take PROVERA 10MG TABLET for 3 months to evaluate if it is still effective in menstrual cycle and to find out how the medicine works.

How do I take PROVERA 10MG TABLET?

A: PROVERA 10MG TABLET use is taken 1 capsule a day, with or without food.

Depo-Provera is a contraceptive used to prevent pregnancy in dogs and cats. The drug can be injected into the body for horses. The medication also treats a variety of other conditions in dogs and cats, including:

  • Treating infertility
  • Treating meningitis
  • Treating gout

Depo-Provera is a contraceptive injection that contains medroxyprogesterone acetate, which is a synthetic form of the hormone progestogen. Medroxyprogesterone acetate is given orally to prevent pregnancy. The medication is injected into the horse’s sphincter muscle. The drug also treats a variety of other conditions in horses, including:

  • Risk of miscarriage
  • Treating aortic aneurysm
  • Risk of aortic dissection

The medication is injected into the body through the sphincter muscle of the horse’s sphincter, which connects the heart to the brain. The drug is used to prevent pregnancy in all types of horses, including both normal and pregnant horses.